Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design

Khalifah RG, Chen Y, Wassenberg JJ. BioStratum Incorporated, 4620 Creekstone Dr., Durham, NC 27703, USA. rkhalifah@biostratum.com Aminoguanidine and pyridoxamine (Pyridorintrade mark), two major inhibitors of advanced glycation end product (AGE) formation, have entered clinical trials for diabetic nephropathy. They share no structural similarity and are believed to inhibit AGE formation by entirely different mechanisms. Pyridoxamine… Read More Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design

AGE – produsii de glicozilare

O reacţie chimică ce produce îmbătrânirea este procesul numit glicozilare. Zahărul se leagă de proteină în interiorul celulelor. Se formeaza pe o cale non-enzimatica prin expunerea normala a hemoglobinei obisnuite la niveluri crescute ale glucozei sanguine. Imbatranirea constituie totalitatea modificarilor biochimice, morfologice si fiziologice ce au ca rezultat descresterea progresiva, in decursul timpului, a capacitatii… Read More AGE – produsii de glicozilare