Lymphotoxin-o, sau pur şi simplu lymphotoxin (LT)

Lymphotoxin-a, or simply lymphotoxin (LT) is a cytokine secreted by activated TH1 cells, fibroblasts, endothelial and epithelial cells (Ibelgauft, TNF-beta, 1999).  LT (a.k.a. Tumor Necrosis Factor-b) is a member of the Tumor Necrosis Factor (TNF) family of cytokines, so named so named because such cytokines were observed to cause necrosis of tumor cells by attacking the surrounding blood vessels, effectively starving the tumor to death (Sompayrac 1999).  LT was first defined by its cytotoxicity to fibroblasts, hence the name “lympho-toxin” (De Togni et al. 1994).  Among the diverse immune functions of LT are the activation and recruitment of effector cells to infection sites, facilitation of leukocyte adhesion to endothelial cells, participation in peripheral lymphoid organogenesis, stimulation of B-cells, and inhibition of tumor angiogenesis.  Lymphotoxin is a proinflammatory cytokine because of its important role in the migration of effector cells to infection sites and has been implicated as a cause of tissue damage in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (Körner et al. 1995, Suen et al. 1997)