In the immune system, the VDR has been detected in activated T cells (7–9), and in cells of the monocyte/macrophage series including dendritic cells, whereas expression on B cells remains controversial (7, 10, 11). As might be expected for an essential nutrient, the effect of vitD3 on immune system function depends upon availability and dose. In mice severely depleted of vitD3, blunted T cell responses have been noted, but in normal animals, vitD3 has generally been found to be immunosuppressive. In CD4 Th cells, vitD3 preferentially inhibits Th1-type cells, particularly the expression of cytokines.
Posted on October 8, 2009
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